Publications

Selected publications

• Wang, K; Dimova, ST; Hanson, JN; Thakur, A; Xu, Y; Liu, Y; Moritz, AE; Goldberg, A; Xie, B; Rayadurgam, J; Wang, F; Nilson, AN; Luderman, KD; Free, RB; Hu, W; Zhang, J; Xu, HE; Frankowski, KJ*; Wang, Y; Shi, L*; Sibley, DR*; Zhuang, Y.* Multiple allosteric sites allow for synergistic enhancement of GPCR signaling BioRxiv 2025 doi.org/10.1101/2025.10.21.683604.
• Xu, M; Alyemni, S; Borin, VA; Majumder, R; Nucci, NV; Keck, T; Frankowski, K; Agarwal, PK; Haider*, S. Asymmetric dynamics between the protomers of the σ2 receptor homodimer J. Chem. Inf. Model. 2025, doi.org/10.1021/acs.jcim.5c02174.
• Moritz, AE; Wang, F; Madaras, NS; Kelley, AM; Snyder, KK; Gandhi, D; Inbody, LR; Akano, EO; Shi, L; Lane, JR; Free, RB; Frankowski, KJ*; Sibley, DR* Discovery, characterization, and optimization of a novel positive allosteric modulator-antagonist of the D3 dopamine receptor J. Med. Chem. 2025, 68, doi.org/10.1021/acs.jmedchem.5c01585.
• Martin, TJ; Martin, CW; Frankowski, KJ; Blough, BE; Aubé, J; Bohn, LM; Jones, SR* Depression of intracranial self-stimulation in male and female rats by intraperitoneal lactic acid: effects of morphine, ketoprofen, and interactions with G-protein biased kappa opioid agonists Psychopharmacology 2025, doi.org/10.1007/s00213-025-06800-3
• Wang, F; Frankowski, KJ* Electrochemical α-functionalization of N-aryl-activated tertiary amines Adv. Synth. Catal. 2024, 366, 3653–3663.
• Wang, F; Frankowski, KJ* Synthesis of (±)-physovenine through electrochemical C–O bond formation Eur. J. Org. Chem. 2022, e202201153
• Kapadia, K; Trojniak, AE; Guzmán Rodríguez, KB; Klus, NJ; Huntley, C; McDonald, P; Roy, A; Frankowski, KJ; Aubé, J; Muma, NA Small molecule disruptors of mutant huntingtin–calmodulin protein–protein interaction attenuate deleterious effects of mutant huntingtin ACS Chem. Neurosci. 2022, 13, 2315–2337.
• Frankowski, KJ*; Patnaik, S*; Wang, C; Southall, N; Dutta, D; De, S; Li, D; Dextras, C; Lin, Y-H; Bryant-Connah, M; Davis, D; Wang, F; Wachsmuth, LM; Shah, P; Williams, J; Kabir, M; Zhu, E;, Baljinnyam, B; Wang, A; Xu, X; Norton, J; Ferrer, M; Titus, S; Simeonov, A; Zheng, W; Mathews Griner, LA; Jadhav, A; Aubé, J; Henderson, MJ; Rudloff, U; Schoenen, FJ; Huang, S*; Marugan, JJ* Discovery and optimization of pyrrolopyrimidine derivatives as selective disruptors of the perinucleolar compartment, a marker of tumor progression toward metastasis J. Med. Chem. 2022,  65, 8303–8331.
• Ma, H; Brust, T; Frankowski, KJ; Lovell, KM; Cameron, MD; Bohn, LM; Aubé, J Advances in sulfonamide kappa opioid receptor antagonists: structural refinement and evaluation of CNS clearance ACS Chem. Neurosci. 2022, 13, 1315–1332.
• Wang, F; Frankowski, KJ* Divergent electrochemical carboamidation of cyclic amines J. Org. Chem. 2022, 87, 1173–1193.
• Potjewyd, FM; Annor-Gyamfi, JK; Aubé, J; Chu, S; Conlon, IL; Frankowski, KJ; Guduru, SKR; Hardy, BP; Hopkins, MD; Kinoshita, C; Kireev, DB; Mason, ER; Moerk, CT; Nwogbo, F; Pearce Jr, KH; Richardson, T; Rogers, DA; Soni, DM; Stashko, M; Wang, X; Wells, C; Willson, TM; Frye, SV; Young,  JE; Axtman, AD Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer’s disease pathology Alzheimer’s Dement. 2022, 8, e12253.
• Potjewyd, FM; Annor-Gyamfi, JK; Aubé, J; Chu, S; Conlon, IL; Frankowski, KJ; Guduru, SKR; Hardy, BP; Hopkins, MD; Kinoshita, C; Kireev, DB; Mason, ER; Moerk, CT; Nwogbo, F; Pearce Jr, KH; Richardson, T; Rogers, DA; Soni, DM; Stashko, M; Wang, X; Wells, C; Willson, TM; Frye, SV; Young,  JE; Axtman, AD AD Informer Set: Chemical tools to facilitate Alzheimer’s disease drug discovery Alzheimer’s Dement. 2022, 8, e12246.
• Frankowski, KJ; Brust, T; Lovell, KM; Yoo, E; Bohn, LM; Aubé, J Structure–activity relationship investigation of triazole-based kappa opioid receptor agonists Med. Chem. Res. 2021, 30, 1386–1396.
• Luderman, KD; Jain, P; Free, RB; Conroy, JL; Aubé, J; Sibley, DR*; Frankowski, KF* Development of pyrimidone D1 dopamine receptor positive allosteric modulators Bioorg. Med. Chem. Lett. 2021, 31,127696.
• Ma, CD; Imamura, M; Talley, DC; Rolt, A; Xu, X; Wang, AQ; Le, D; Uchida, T; Osawa, M; Teraoka, Y; Li, K; Hu, X; Park, SB; Chalasani, N; Irvin, PH; Dulcey, AE; Southall, N; Marugan, JJ; Hu, Z; Chayama, K; Frankowski, KJ; Liang, TJ Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion Nat. Microbiol. 2020, 5, 1532-1541.
• Klus, NJ; Kapadia, K; McDonald, P; Roy, A; Frankowski, KJ; Muma, NA; Aubé, J Discovery of sultam-​containing small-​molecule disruptors of the huntingtin-​calmodulin protein-​protein interaction Med. Chem. Res. 2020, 29, 1187–1198.
• Moritz, AE; Free, RB; Weiner, WS; Akano, EO; Gandhi, D; Abramyan, A; Keck, TM; Ferrer, M; Hu, X; Southall, N; Steiner, J; Aubé, J; Shi, L; Frankowski, KJ*; Sibley, DR* Discovery, optimization, and characterization of ML417: A novel and highly selective D3 dopamine receptor agonist J. Med. Chem. 2020, 63, 5526–5567.
• Vilimas, T; Wang, AQ; Patnaik, S; Hughes, EA; Singleton, MD; Knotts, Z; Li, D; Frankowski, K; Schlomer, JJ; Guerin, TM; Springer, S; Drennan, C; Dextras, C; Wang, C; Gilbert, D; Southall, N; Ferrer, M; Huang, S; Kozlov, S; Marugan, J; Xu, X; Rudloff, U Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer Cancer Chemother. Pharmacol. 2018, 82, 1067–1080.
• Luderman, KD; Conroy, JL; Free, RB; Southall, N; Ferrer, M; Sanchez-Soto, M; Moritz, AE; Willette, BKE; Fyfe, TJ; Jain, P; Titus, S; Hazelwood, LA; Aubé, J; Lane, JR; Frankowski, KJ; Sibley, DR Identification of positive allosteric modulators of the D1 dopamine receptor that act at diverse binding sites Mol. Pharmacol. 2018, 94, 1197–1209.
• Frankowski, KJ; Wang, C; Patnaik, S; Schoenen, FJ; Southall, N; Li, D; Teper, Y; Sun, W; Kandela, I; Hu, D; Dextras, C; Knotts, Z; Bian, Y; Norton, J; Titus, S; Lewandowska, MA; Wen, Y; Farley, KI; Griner, LM; Sultan, J; Meng, Z; Zhou, M; Vilimas, T; Powers, AS; Kozlov, S; Nagashima, K; Quadri, HS; Fang, M; Long, C; Khanolkar, O; Chen, W; Kang, J; Huang, H; Chow, E; Goldberg, E; Feldman, C; Xi, R; Kim, HR; Sahagian, G; Baserga, SJ; Mazar, A; Ferrer, M; Zheng, W; Shilatifard, A; Aubé, J; Rudloff, U; Marugan, JJ; Huang, S Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis Sci. Transl. Med. 2018, 10, eaap8307.
• Chun, LS; Vekariya, RH; Free, RB; Li, Y; Lin, D-T; Su, P; Liu, F; Namkung, Y; Laporte, SA; Moritz, AE; Aubé, J; Frankowski, KJ*; Sibley, DR* Structure-activity investigation of a G protein-biased agonist reveals molecular determinants for biased signaling of the D2 dopamine receptor Front. Synaptic Neurosci. 2018, 10, 2.
• He, S; Li K; Lin, B; Hu, Z; Xiao, J; Hu, X; Wang, AQ; Xu, X; Ferrer, M; Southall, N; Zheng, W; Aubé, J; Schoenen, FJ; Marugan, JJ; Liang, TJ*; Frankowski, KJ* Development of an aryloxazole class of hepatitis C virus inhibitors targeting the entry stage of the viral replication cycle  J. Med. Chem. 2017, 60, 6364–6383.
• McLeod, MC; Aubé, J; Frankowski, KJ* Decahydrobenzoquinolin-​5-​one sigma receptor ligands: divergent development of both sigma 1 and sigma 2 receptor selective examples Bioorg. Med. Chem. Lett. 2016, 26, 5689–5694.
• Scarry, SM; Lovell, KM; Frankowski, KJ; Bohn, LM; Aubé J Synthesis of kappa opioid antagonists based on pyrrolo[1,2-α]quinoxalinones using an N-arylation/condensation/oxidation reaction sequence J. Org. Chem. 2016, 81, 10538–10550.
• Kuramoto, K; Wang, N; Fan, Y; Zhang, W; Schoenen, FJ; Frankowski, KJ; Marugan, J; Zhou, Y; Huang, S; He, C Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids Autophagy 2016, 12, 1460–1471.
• Gui, L; Zhang, X; Li, K; Frankowski, KJ; Li, S; Wong, DE; Moen, DR;, Porubsky, PR; Lin, HJ; Schoenen, FJ; Chou, TF Evaluating p97 inhibitor analogues for potency against p97-p37 and p97-Npl4-Ufd1 complexes Chem Med Chem 2016, 11, 953–957.
• He, S; Jain, P; Lin, B; Ferrer, M; He, Z; Southall, N; Hu, X; Zheng, W; Neuenswander, B; Cho, C-H; Chen, Y; Worlikar, S; Aubé, J; Larock, RC; Schoenen, FJ; Marugan, JJ; Liang, TJ*; Frankowski, KJ* High-throughput screening, discovery and optimization to develop a benzofuran class of hepatitis C virus inhibitors ACS Comb. Sci. 2015, 17, 641–652.
• Frankowski, KJ; Liu, R; Milligan, GL; Moeller, KD; Aubé, J Practical electrochemical anodic oxidation of polycyclic lactams for late stage functionalization Angew. Chem. Int. Ed. Engl. 2015, 54, 10555–10558.
• Frankowski, KJ; Slauson, SR; Lovell, KM; Phillips, AM; Streicher, JM; Zhou, L; Whipple, DA; Schoenen. FJ; Prisinzano, TE; Bohn, LM; Aubé, J Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif Bioorg. Med. Chem. 2015, 23, 3948–3956.

For a complete list of publications see PubMed